Tumorigenic Transformation of Rat Bone Cells by Benzo(a)pyrene

No-Hee park³, Gene Lee¹, Jae-Seung Ko², Kyung Mi Woo¹^.*, Joong-Ki Kook¹, Byung-Moo Min¹⁺

³UCLA Dental Research Institute, Los Angeles, California 90024, U.S.A
Department of ¹Oral Biochemistry and ²Oral Anatomy and Dental Research Institute,,College of Dentistry, Seoul National University Seoul 110-749, Korea

Abstract

Key Words : osteoblast-enriched cells,benzo(a)pyrene,malignant transformation,proto-oncogenes,tumor suppressor genes